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Dr. Benjamin Bikman - 'Insulin vs. Ketones - The Battle for Brown Fat'

  • Published on Mar 16, 2017
  • Dr. Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. He is currently a professor of pathophysiology and a biomedical scientist at Brigham Young University in Utah.

    Dr. Bikman's professional focus as a scientist and professor is to better understand chronic modern-day diseases, with a special emphasis on the origins and consequences of obesity and diabetes, with an increasing scrutiny of the pathogenicity of insulin and insulin resistance. He frequently publishes his research in peer-reviewed journals and presents at international science meetings.

    Dr. Bikman has long been an advocate of a ketogenic diet in light of the considerable evidence supporting its use as a therapy for reversing insulin resistance. His website InsulinIQ.com promotes dietary clarity, healing, and freedom through evidence-based science about insulin resistance. Employing cell-autonomous to whole-body systems, Dr. Bikman's recent efforts have focused on exploring the intimate associations between the metabolic and immune systems.
  • Science & TechnologyScience & Technology

Comments • 507

  • Rufus Sweeney
    Rufus Sweeney 4 years ago +286

    Dr. Bikman was my teacher for pathophysiology at BYU. He's a wonderful lecturer; his class was life-altering. Now, I'm doing research with the professor with whom he did his post-doc. I've become a champion of this message. In fact, I've started a podcast aimed at distilling a clear picture of what the current literature has to say about nutrition for the layman.

    If anyone is interested in talks like this, they'll enjoy the podcast. It's called Peer-Refined Health, and the first episode will be coming out later this month.

    • FeelingShred
      FeelingShred Year ago +1

      @KNUCKLES What you report there in regards to the frutarian diet seem to match this video that I just saw, something in regards to "Starvation happening even when there is input of calories" ru-clip.com/video/0E0SZTV1dFg/video.html

    • James Clary
      James Clary 2 years ago +1

      Looking forward to it

    • James Clary
      James Clary 2 years ago

      maxgotsmart Why? Seems silly.

    • R C
      R C 2 years ago

      Rufus I looked for this and couldn't find it. Do you have a link?

    • Mary Miranda
      Mary Miranda 2 years ago

      Mind blown 🤯 Thank you for this 🙏🏻

  • Joseph Bates
    Joseph Bates 3 years ago +392

    WoW! Love this talk. My son did the "keto" diet about a year ago and turned me on to watching Dr Berg keto talks on RU-clip. I started my keto journey on Dec. 8th, at 477 lbs. As of Feb. 27th (2.5 months), I'm down 50# (427) and couldn't be more ecstatic. My cravings for food are minimal and mostly psychological at this point. I've reduced intake to about 2 meals a day with little interest for more. I do one meal a day "OMAD" at least once a week. I came off my insulin (was taking U-500) within days and am now starting to wean off my blood pressure meds. I really appreciate this deeper dive you've done into the science and that you're making it public. I hope you'll be able to do a collaborative video with Dr Berg soon because I think more people would appreciate the additional evidence. This is life changing affects the person doing it and all around them. Best of luck to you as you continue your work and thank you!

    • Mark Fox
      Mark Fox Month ago

      Hope you're still on your KETO journey, Joe. Good luck.

    • Scott Herford
      Scott Herford 2 months ago

      Listen what Berg’s son says about Peter. He’s on utube.

    • Phil B
      Phil B 6 months ago

      how many units of the U -500 were you taking per day

    • Josie Stev
      Josie Stev 9 months ago +1

      @Matthew Wright
      How are you doing? I has been one year. I’m down at least one pant size since Oct.

    • Ivy Snow Filly Videos
      Ivy Snow Filly Videos 11 months ago

      Thank You for sharing ur story. Very inspirational ❤

  • Linda McNeil
    Linda McNeil 2 years ago +63

    I have watched this several times... and this lecture is one of the best lectures that describes the rudimentary mechanisms of the metabolic effect of food. Thank you for al, your heard work.

    • David McIver
      David McIver 5 months ago +3

      The last sentence has a typo, “heard”. That is ironic because we are heard animals that this advice helps a lot.

  • Journeyman
    Journeyman 4 years ago +128

    Brilliant explanation of what I have been doing wrong all my life and how to fix it, it really hits home for me at 11:00 in this video. Thanks for the education would be an understatement - thumbs up!

  • Ralf Stores
    Ralf Stores 3 years ago +53

    DR Bikman is an amazing presenter, objective, articulate. Not the least bit offensive or obnoxious like some. It is a pleasure to watch and listen.

  • M Freeman
    M Freeman 4 years ago +46

    Completely brilliant and fascinating! I've been so incredibly impressed with the humble and enthusiastic way you present your research. After watching this I'm so grateful to have a better understanding of why and how Keto works and how it relates to my own issues with diabetes and insulin resistance. Thank you!

  • Brian Chandler
    Brian Chandler 4 years ago +16

    Thanks for putting this up. You've provided some of the best information I've found on how insulin comes into play. I now no longer need my Metformin from maintaining a strict Ketogenic lifestyle, but now I understand more about why that is.

    • Kim Miller
      Kim Miller 2 years ago

      How does Metformin play into this?

  • Klaudia Valentova
    Klaudia Valentova 4 years ago +12

    Great...it helped me a lot to understand relation between keto nutrition and ice swimming...I was swimming second winter in ice waters and it improves my termoregulation by changing white fat cells to brown fat cells. But nobody could explain it like this!! (thanks to this video!!) It feels great. And this winter I also started with keto nutrition...it should help us even more with better thermoregulation which is connected with better immunity too. 👍

  • Robin Jacobi
    Robin Jacobi 3 years ago +5

    I am thankful that you have given us the science behind the keto diet.
    Im finally losing the fats.
    I didnt count calories, however, now I do because eating proteins and maybe a little to much fat (which was measured in tablespoons) causes me to retain fat. I can only assume im extremely insulin resistant.

    So very thankful for this research!

  • Drake Santiago
    Drake Santiago 4 years ago +29

    What a wonderful presentation. This is definitely one I will keep in m video playlist, and reference when someone speaks about caloric consumption being the sole determinant of weight loss and maintenance. Thank you for this.

  • Will Thorpe
    Will Thorpe 4 years ago +3

    This is fantastic. Love LCHF diet but never heard the science behind it explained like this. Thank you!

  • Elisa Frye
    Elisa Frye 2 years ago +1

    Thank you, Professor Bikman! You have explained the complex metabolic reaction of our bodies to carbohydrates, protein, and fat so clearly that I think even a fairly uninformed person can understand the role of carbohydrates and insulin in fat deposition. I am going to point out your presentation to several type 2 diabetics who think I’m nuts for controlling my type 2 Diabetes strictly through diet-a diet greatly made up of-OH HORRORS-FAT!

  • JJ Malvarez
    JJ Malvarez 2 years ago +1

    Excellent talk...Good for those on Keto and also for those in Intermittent fasting. A must watch for Diabetics to understand more about what's going on in their bodies.

  • Zen Life
    Zen Life Year ago +1

    I watched it once. Then sat down and watched it again this time taking NOTES. I needed to participate in order to fully absorb what he was teaching. Great stuff! Information like this helps people like me say no to carbs with a sense of purpose. No insulin thank you. I'll be eating ketones for the win. Go Chiefs!

  • CalebO1996
    CalebO1996 4 years ago +61

    Fascinating! Very, VERY enlightening. I had a sense of sheer amazement throughout Dr. Bikman's lecture.

    Imagine a scenario:

    Spring comes in the paleolithic era and Grog the Caveman comes across a patch of delicious berries. He and his tribe gorge on them to excess, storing an abundance of white adipose tissue on their body.

    Autumn comes, leaves fall and the sweet fruits of nature dry up and wither away. Grog has to figure something else out. Luckily some animals are migrating south for the winter. He and his tribe snag a few to bring along as pack animals until they arrive at their new home... Little did they know they'd be some winter chow soon.

    Winter brings terribly cold weather. We have not used slavery and pollution to create a huge clothing industry yet so the only options to stay warm are fire (if we know how to make it) or relying on body chemistry to help. Since we haven't seen any berries in a while, our insulin sensitivity is high and ketogenesis begins. That fatty caribou didn't taste too bad either.

    That WAT is converted slowly to BAT as discussed and out come ketones. Not sweet smelling urine mind you (like those with major insulin insensitivity and glucose in the blood), but pee rich in ketones. Caloric waste. Some nice warmth is gained from the thermogenesis resulting from the BAT and Grog lives to see Santa Clause and ring in the New Year once more.

    Congrats Grog, you really know how to use your body to your advantage!

    Now that we have clothing, air conditioning, a strange lack of ice ages, year-round fruit and grains, among other modern comforts people couldn't live without, the body does not need to use all of its facilities to keep us comfortable and healthy..... but that's exactly what it has evolved to do.

    • Adam Amoroso
      Adam Amoroso Year ago +1

      But what's missing from both your Grog the Caveman scenario and the talk is the evolutionary and/or the physiological rational for the energy waste involved in ketosis. Is the waste a feature or a bug? From an evolutionary perspective it is understood that energy must be conserved to the greatest extent possible - our survival depended on it. The entire insulin system as I understand it is based on that idea in that it directs our bodies to store the energy that is not needed in any given moment. When carbs become scarce in the winter, as you mention, or in times of food scarcity generally the body can switch into an alternative energy system where it can now use the energy that it has stored in times of plenty. It wouldn't want to waste that energy. Presumably it even takes energy to break lipids down into the various components as Dr. Bikman covered. This seems to be an inefficiency that I'd like to be able to reconcile. Does it have to do with the starvation metabolism vs ketogenic diet? In other words is the body just not able to well-regulate the available energy against what it needs to function in any given moment, given that the lipid energy is being consumed rather than harvested from the body itself? I feel like I might be answering my own question to some degree here, but it would still be nice to hear the experts address it. And in addition it still seems like a surprising inefficiency that the body did not adapt a way to store excess energy in this alternative, ketogenic energy system. Though perhaps the explanation is revealed in the fact that it is a starvation energy system. If that is the case though I'm still curious how that explanation interplays with the other aspects of this system like the brown fat Dr. Bikman is studying. Does brown fat play any role in starvation metabolism? If indeed ketosis can be thought of as 'starvation metabolism', at least evolutionarily speaking, and it explains the energy waste involved, why wouldn't the body have adapted a way to store the excess energy during those lean times, as it would have been so much more vital for survival?

    • Y. G.
      Y. G. 2 years ago +3

      good tale, Caleb. One correction on clothing, though. Buying hundreds of clothing items for pure consumerism is certainly fairly modern phenomena (produced by cheap labor, yes), but the caveman Grog was smart enough to use animal skins and fur for clothing !! This should have been obvious to you. Since I was like ~9 years old, I remember from school, the posters of 'cavemen' wearing that and holding big stones and bats in their hands.

    • OperatorJon
      OperatorJon 2 years ago +3

      @Lou Bob There's enough fat to go around, the issue is protein. We could easily get that from insects though. But no one really wants to, I wonder why 😂

    • Lou Bob
      Lou Bob 3 years ago +2

      A very good explanation. The elephant in the room is always that if most humans (6 billion +) started eating like this, the planet would be void of all animal life. Keep this secret to ourselves?

    • k14michael
      k14michael 3 years ago +5

      Caleb - best explanation EVER!

  • Arina Thomsen
    Arina Thomsen 4 years ago +6

    Brilliant and absolutely necessary research. Thank you, Dr. Bikman! I hope your ideas will become very widely spread in the modern medical field and among the general population.

  • Helmut Gottschalk
    Helmut Gottschalk 4 years ago +32

    Thank you so much for sharing this information. Keto diet has changed my life for the better after 50 years of being overweight. Now I know more about what's going on in my body and can pay even more attention to what I put in it.

  • BioMonkey w/ Paul Lauener
    BioMonkey w/ Paul Lauener 4 years ago +81

    This is one of the best explanations for the difference between glucose and ketone sources of energy. Brilliant!

  • Farhan Yazdani
    Farhan Yazdani 2 years ago +5

    Thank you for yet another clear and informative presentation.
    One question that remains is to understand to what point ketones themselves have an effect on the metabolic pathways and cellular inflammation and to what extent they are merely an index of the glucose shortage and the opening of the decarboxylation pathway.

    Do ketones have an anti-inflammatory effect or does the glucose shortage starve intracellular germs and viruses that produce inflammation?

    In so many ways, the valiant band of metabolic explorers you represent remind me of the feats of Livingston and Stanley discovering Africa.

    • YeshuaMyKing
      YeshuaMyKing 2 years ago

      Its pretty well proven that ketones themselves are the key, having the effect. Dr Boz has some vids on this. Shes very much in brain healing n healed her mom of cancer.

  • Nikki Guerlain
    Nikki Guerlain 4 years ago +11

    What a great lecture! Thank you!

  • Luvin Itall
    Luvin Itall 2 years ago +1

    What an amazing presentation. For me, as a non-academic (certainly non-scientific or medical), this made complete sense and was easy to understand - the use of the slides to support / explain the findings was great (ok - I DID have to pause a few of the slides to make sure I understood the graphical correlations).

    I hear some recent concerns about keto diet effects on the kidneys for diabetics. I'm Type 2 - although moderating my diet so comfortably at pre-diabetic levels. Would be keen to hear if there has there been any new information since this presentation that might be relevant to diabetics.

  • Elen bokhari
    Elen bokhari 2 years ago +1

    A very informative talk! However, as a next step would be interesting to understand wider physiological effects of the ketogenetic diet, I.e. cardiovascular health, dementia and cancer. As well, if this type of diet can be used during the whole human life span or only at certain pre-diabetic states. Again, well done!

  • Doctor.S
    Doctor.S 3 years ago +6

    love it.. so good to hear him, it solves many of my questions, thank you for doing this.

  • My Journey
    My Journey 4 years ago +8

    This is a fantastic video. I've been getting into a ketogenic diet lately as well as doing the Wim Hof method which advises cold showers that build brown fat.

    • Ivy Snow Filly Videos
      Ivy Snow Filly Videos 11 months ago +1

      Interesting about ur workouts.
      I sleep with my room temp@50f & swim in cold water from mountain snow. Im always hot.

    • Sid Michael
      Sid Michael Year ago


    • Unexcelled
      Unexcelled 2 years ago +1

      Wim Hof is the real deal. The science Dr. Bikman is presenting coorelates with the cold exposure. Dr. Bikman explains it extremely well. The Wim Hof method helps the body develop brown fat. The brown fat also has a positive effect on the immune system.

      That's just one part of what the Wim Hof method does. Concentrating on the cold while breathing similar to what a free-diver would can cause the brain to develop new pathways that can literally control automatic body functions. It's essentially a way to become a monk. I myself can now release adrenaline, or dopomine- not unlimited amounts but enough to make me twice as strong in the gym with a burst of adrenaline, or calm down from a stressful situation with a few breaths and a release of dopomine.

      I've barely scratched the surface having done the method for a couple of months.

  • burritos
    burritos Year ago +3

    For the year and a half, I've done 20-24 hr dry fasts 3-4 times a week. Also I've only taken daily cold showers. Now, I haven't totally stopped my carb in take, but I suspect the dry fasts have upregulated my mitochondrial activity and increased my brown fat. In the past when I would sleep (especially in the winter), I would curl up in my blanket all night long, especially during the winter. This has been since I was a kid. Now I find myself waking up in the night having to remove the blanket cause I feel hot. If I haven't thrown off my blanket, I'm a lot more sweaty as compared to before. The last time I did this regularly was when I was a kid. This was probably a time when I had more brown fat and wasn't the product of decades of carb intake.

  • Ben Zei
    Ben Zei 10 months ago

    Really good lecture, easy to understand. Great career choice as a professor

  • Inaki Legorburu
    Inaki Legorburu Year ago +3

    Great talk! What I found fascinating was the graph from the David Ludwig study starting at 26:30, where the metabolic rate for the low carb high fat diet continues to rise and stay high for 4-6 hours after the meal. Are there any other studies that have built on this study by looking at meal frequency and IF over a longer time span 24-72 hours?

    • Paco Javo
      Paco Javo Month ago

      Just watched the video and I was exactly thinking the same regarding HFLC meal metabolic reaction, and if it keeps improving if next meals are also HFLC 👍

  • Craig McIntier
    Craig McIntier 3 years ago +4

    This answered so many of my questions. Awesome talk!

  • Muscles Mouse
    Muscles Mouse 2 years ago +1

    wow, this is happening in my body. I feel hotter and my wife feels the heat also. so the ketones she smells is my fat burning. this really helps me understand what is happening.

  • Loretta Dillon-Ham
    Loretta Dillon-Ham 2 years ago

    Thank you.
    Once the weight loss settles ...
    I'd like to know how we as individuals can identify when and if we are converting our white fat to brown fat and what are the visual indicators that prove we are doing this (apart from weight loss) - especially once our weight loss subsides. Is it then the addition of exercise is required ??? that will be the trigger for that exchange?

  • Marqus Aurelius
    Marqus Aurelius 2 years ago +3

    Absolutely fascinating. Thank you for the presentation.

  • Mobius Trip
    Mobius Trip 4 years ago +20

    Brilliant presentation, way, way ahead of its time...

  • TheFogskum
    TheFogskum 4 years ago +2

    Absolutely fantastic presentation!

  • Roger Bird
    Roger Bird 5 months ago

    I love this guy. His thinking is so clear and easy to understand. I think I'm going to subscribe to his channel, if he has one.

  • William Xie
    William Xie 2 years ago +4

    Brilliant talk, chock full of scientific information which will take many views by this totally biomedical- ignorant person to understand and absorb.

  • James Schultz, Ph.D.
    James Schultz, Ph.D. 3 years ago +7

    Interesting how the endocrine theory engulfs the caloric theory - you explained this really well! I also never realized that that there are two different kinds of fat tissue: white and brown...fascinating!

  • Dr. Ala Lysyk
    Dr. Ala Lysyk 3 years ago +2

    What a fantastic lecture.

  • Jim Cameron
    Jim Cameron 4 years ago +62

    Very good video and very timely. It is concerning to me that similar video topics without any substance garner 1000s of views, while the complex and substantive videos like this one are not readily viewed. It suggest to me that there is a large role for policy on this and education generally.

    • Space Ghost
      Space Ghost 3 years ago +4

      Because lazy people just want a quick sound bite. Most are far too stupid and/or lazy to actually dig into some numbers.

  • Gabrielle Angel Lilly
    Gabrielle Angel Lilly 4 years ago +6

    Thank you for sharing this fascinating and valuable research!!

  • Robert Chew
    Robert Chew 2 years ago +1

    Dr. Bikman knows this stuff so well. Love it. No notes or anything !!

    JUST TAKE A LOOK 3 years ago +14

    The Video that cleared up why some people cant lose weight, Thanks BB

  • ⃢      ✅
    ⃢ ✅ 2 years ago +42

    If anybody wants this in more scientific and historic detail, please watch _The Aetiology of Obesity_ by Dr. Fung. It is a 6-8 hour lecture on the same topic.

  • Julie Gale LCHF81
    Julie Gale LCHF81 4 years ago +25

    Some how that explains a lot to me a non academic, about how keytones work on our fat. Think I need to watch it again. Shall share on #LCHF81 Great research.

  • armadillotoe
    armadillotoe Year ago +2

    I have been very strictly to pretty much keto for about 18 months. I devour information on keto, health, and weight loss. This is the 1st time I have seen an actual reason why eating so much fat is a good thing when inducing ketosis. I hate blindly following instructions, and love knowing why I should do things. More dietary fat means less insulin. This also explains when I began the keto diet, I was so hot, and minimal exertion would cause me to sweat uncontrollably. I could take a long cold shower, and before I could dry off, I was sweating again. When fat is "burned" it actually is turned into carbon dioxide, and water. If you are more rapidly burning fat than can be expelled as water and carbon dioxide, breathing and whizzing out ketones (converted fat) makes perfect sense. This is the best explanation of the ketogenic diet I have ever seen.

    • kickn-aDead-cat
      kickn-aDead-cat Year ago +1

      The insulin roller coaster is what finally messes with your pancreas. That’s why doctors have it backwards they try to control glucose when they should be to controlling insulin for type 2.

  • V Jr
    V Jr 4 years ago +11

    amazing vid, i recently read Dr Volek's research on high level endurance athletes, high carb vs low carb, and i think this accounting discrepancy came up, was actually wondering about how that worked out, guess this sort of answers it!

  • JB Fitness
    JB Fitness 3 years ago +3

    Very cool presentation, I want all my fat to be BAT! haha - but in seriousness, it is very interesting to see the connection between fat tissue with insulin & Ketones.

  • Trevor Folgering - Biohacking Coach

    So Interesting and wonderful data! I love this! ❤️

  • OscarMikeOut
    OscarMikeOut 2 years ago

    With all this content, this channel is really underrated. Great stuff.

  • Mabel Heinzle
    Mabel Heinzle 2 months ago

    Thank you Sir - this knowledge will save lives

  • Peter Faber
    Peter Faber 3 years ago +20

    What people are completely unaware of, (and in my opinion the scientists don't emphasize this enough), is that metabolic rate varies depending on what you eat and how often you eat.

    It doesn't vary a little bit, but enormous. Metabolic rate between 2 people with equal health, same weight and bodyfat percentage, on different diets of the same amount of calories, can be different as much as 50%. Fifty percent!!!!!

    Reducing calories just drops your metabolic rate by about the same amount of calories. Nobody seems to be aware of this.

    The problem is that this effect is somewhat hidden because it's not instant. At first you burn through glycogen. Glycogen stores are about 2 to 3 kg of glucose and water and they are in the muscle and liver. That's the first week of dieting. After that first week, the metabolic rate starts to drop to match the caloric intake. And it's when the real suffering starts: Feeling cold, constantly thinking about eating, living from meal to meal, grumpiness, etc.

    If people could only really understand these shifts in metabolic rates, they wouldn't even try to just simply cut calories.

    It is weird as hell. I've explained this to people and even if they say they understand, the only possible effect is that they start a low calory diet because they became aware (again) they need to lose some weight. It's like trying to convince mormons that god doesn't exist. A total waste of time.

    • Elisa Frye
      Elisa Frye 9 months ago

      @Monnie Holt YOU OBVIOUSLY KNOW. NOTHING about any faith but your own narrow little view...WATCHTOWER HAS NOTHING TO DO WITH MORMONISM, you dolt! ( And I am NOT a Mormon, just someone who has more knowledge of religious publications than you!

    • Monnie Holt
      Monnie Holt 2 years ago

      @Jake Davidson actually the Bible that Mormons use is not the Bible. There are several places where words are changed. There are several ministries online to look into showing Mormonism is a cult. Jesus Christ is part of the Godhead, the Trinity, the three in one, and that's the major doctrine Mormons reject. Compare the watchtowers Bible with the KJV. Ephesians 2:8-9:
      "For by grace are ye saved through faith; and that not of yourselves: it is the gift of God: Not of works, lest any man should boast.". Works based salvations like Mormonism's are heretical towards the Bible. You cannot earn your way, and saying you can is prideful. Jesus paid it all. We only need to trust in him. That's what the Bible teaches.

    • Karin Logtenberg
      Karin Logtenberg 2 years ago

      @Jonathan Thomas Clearly you don't know anything about Mormonism, so sad....

    • Jake Davidson
      Jake Davidson 2 years ago +1

      @Jonathan Thomas funny you say we reject the bible as we are currently studying the sermon on the mount in my gospel doctrine Sunday school class and have been going through Christ's ministry all year... Also if you were unaware the speaker Benjamin Bikman is a very active member of the Church of Jesus Christ of latter day saints.

    • Jonathan Thomas
      Jonathan Thomas 2 years ago +4

      God does exist though. The universe proves it.
      Mormons simply reject the Bible. And write their own (one which hasn’t been authenticated by fulfilled prophecy.)

  • Ian Chabot
    Ian Chabot 2 years ago

    Although not speaking to some very important mechanisms, this was a very informative lecture.

    Having said that, with time restricted feeding, I eat nothing but green, yellow,and starchy vegetables, the occasional fruit, legumes,, select whole intact grains and seeds yet have fasting insulin levels below “normal” 🤔 range. I also WOF (nature’s true keto) for 2 days, 64 hours, as occasional resets .Curious.

    mTOR, IGF-1, telomeres all good

  • Cherie Ambrose
    Cherie Ambrose 4 years ago +2

    This heat theory... I need to know more. I've been doing keto for seven months, have lost 35 pounds, and I stalled when my gallbladder decided to get irritated. It was never infected or inflamed, but it was definitely being used hard maybe for the first time in my life. Now that I'm healed from that trauma and am watching spicy foods, I find myself getting really warm right before bedtime. And, I'm finally losing weight again. Is this heat metabolism? It almost has to be. I've done bloodwork that proves all my numbers are good and no infection. The liver is the center of metabolism, and this heat centers around my core right where the liver is. Any ideas? When I say heat, my temp rises about one to two degrees right before bedtime.

    • Jon Anderson
      Jon Anderson 3 years ago

      Start eating fruit daily but don't mix it with fat.

    • Jon Anderson
      Jon Anderson 3 years ago

      Thermogenesis. You are eating more calories than your body needs so it burns it and converts it to heat. Try eating less. Could be it.

    • Cherie Ambrose
      Cherie Ambrose 4 years ago

      @Jefferdaughter thank you for the info. My gallbladder seems perfectly fine now after its freak out. Nothing hurts. I love spices, but I have been watching spicy pepper spices, if that makes sense? Generally I'm finding the warm temperature rises happening at random times now, so I've decided to keep a food journal to track everything. I have avoided processed foods and oils for two years. I'm pretty much whole foods now. Healing is my goal. Now that my gallbladder is fine, I'm losing weight again, slowly but steadily. I do a lot of research, so I'll continue to dig deeper. I have found healing in nutrition. Doctors do not tell you anything and only want to mediate symptoms.

    • Jefferdaughter
      Jefferdaughter 4 years ago +2

      Cherie, you may want to contact directly someone who is doing research on low cab high fat diets and/or nutritional ketosis in humans. Others have had similar experiences, but it is unlikely that other viewers will have any useful information on your body temperature rise in the evening. Dr. Jason Fung would probably suggest that you consider brief occasional fasts, which could give your gall bladder a chance to rest and repair itself. He says that short fasts have many health benefits, which include allowing the body to more effectively maintain and repair itself. Videos featuring him are here on YT.I'm not always sure what people mean when they say 'spicy foods'. Spices are generally very beneficial, as they contain compounds that can be very healthful but which are not often found in other sources. The quality of the fat we eat is, as you most likely know, very important, whatever the level of fat is in our overall diet (original meaning of the word, as in 'the sum total of all we eat'). Avoiding processed foods is a key to health regardless of the percentage of fat we consume, so we should all avoid processed oils like corn and soybean oil. If there are no other issues except feeling warm in the evening, I wonder if this is an issue at all, really? Have you tried shifting when you eat, maybe eating in the morning and midday or early afternoon, rather than at 'dinner time'? Just a thought... Hope you are able to find the answers you seek.

  • Richard Jehl
    Richard Jehl 3 years ago

    Very good and useful info ! Thank you !

  • Coyley
    Coyley 4 years ago +4

    Outstanding presentation, +Low Carb Down Under
    My challenge is that I'm an IDT2D - sounds like a Star Wars robot :) - and on a very low carb diet. But because I still have to take insulin I believe this is impacting the rate at which I am burning fat. I am in ketosis, as my testing tells me, but it appears fat burn is much slower. It's a bit of a catch 22.

    • Sublime
      Sublime 3 years ago +2

      Watch dr fung...he will have an answer for you

    • Jungles Bongles
      Jungles Bongles 4 years ago +1

      i watched another video that said the presense of insulin tries to prevent the body from going into ketosis.

      the body will not (normally) go into ketosis with insulin present until all insulin is gone which can take 2 weeks (for a fat person on high calories).

      so one day of high carbs, no fat burning ketosis for 2 weeks for us fatties... maybe quicker for normals.

      in your case bcuz u are doing lchf there is no extra glucose to consume you would otherwise be in a ketosis mode but the insulin prevents the ketosis.

      so you are in ketosis if youre losing weight but arent if the insulin prevents it. just what this video was saying about insulin wanting to make white fat cells and ketosis brown fat cells.

      thats probably a contradiction to the body.

      u should probably quit insulin and see if u go inti ketosis and lose weight but hey... I'm most definitely not a doctor. if you have diabetes or smth... thats your doctors decision. then again you probably dont need that insulin anymore at least bcuz of this but might for some other diabetes reason.

    • BigBen Hebdomadarius
      BigBen Hebdomadarius 4 years ago

      Surely it is possible to adjust your insulin dose to compensate for the change in glucose levels?

  • Better Life Broadcasting
    Better Life Broadcasting 4 years ago +8

    YAy! Thermo geekiness! Also.. as regards the restricted calorie vs. ad libidum groups, one group also wasn't feeling angry, controlled by outside forces and resentful. That makes a HUGE difference in whether a person is going to keep the weight off after the diet.

    • Better Life Broadcasting
      Better Life Broadcasting 4 years ago

      I appreciate the question! But I think it probably does. I mean, we all sign up for work and are compensated for it too, but that doesn't stop us from resenting it on occasion. And then, having been "told what to do" there's an almost inevitable bit of rebellion once a person is "free" of the restriction.

    • Jefferdaughter
      Jefferdaughter 4 years ago

      Interesting thought. But does that really apply to people who voluntarily signed up for a study? And were most likely compensated for their participation?

  • Michael Dillon
    Michael Dillon 5 months ago

    This ties up with something I heard on a Dr Fung talk where he mentioned that nearly a hundred years ago it was discovered that diabetics ( insulin deficient !) expend about 30O kcalories a day . Incidentally I saw a documentary about brown adipose tissue on TV at least 30 years ago , so like a lot of this knowledge it has been around for years . Thank goodness these brilliant people are putting all this knowledge together and applying it in the clinical setting ( goodness knows we desperately need it ) . Great talk doctor 👍

  • Bilbo Beutlin
    Bilbo Beutlin Year ago

    Fantastic lecture Dr. Bikman
    How would you explain constant blood ketone levels between 0.1 and 0.5 mmol/L in subjects eating one meal per day consisting only of fatty fish and fatty meat?

    • Winsome Cohall
      Winsome Cohall Year ago +1

      What is your glucose measuring.. got to burn up the stored sugar then your ketones will go up also eating fatty cuts of mean and 20 grams carbs TOTAL not net carbs

  • zzcaptain (Mast IV)
    zzcaptain (Mast IV) 2 years ago

    very well done Doc Bikman & thank you for talking about function, just another reason why i did not pass microbiology in juco college (twice) five star *****5*****especially at a time when the Wim Hoff method is being used & in your words may be "remarkably related".

  • JB Fitness
    JB Fitness 3 years ago +6

    I frigging love this presentation. Thank you Dr. Ben Bickman

  • Fábio Arruda
    Fábio Arruda 3 years ago +17

    An interesting thing that crossed my mind while watching is that when we are getting fat in nature is when we hunt, and to hunt we need to run a lot, and to run a lot we cannot be heavy.

  • David McIver
    David McIver 5 months ago +1

    On a keto diet I continue to lose weight although I am eating a lot more. I am never hungry, have tons of energy at 76 ( 4 hours of pickleball 5 days a week) and the brain seems to be cooking well.

  • Jim D
    Jim D 3 years ago +5

    OUTSTANDING presentation. Just awesome.

  • cojanti
    cojanti 4 years ago +3

    The science is clear and intriguing - thank you. However, the term 'metabolic advantage' is highly subjective: for the vast majority of human history calories have been in short supply, so to store and not to waste energy would have been advantageous. Could it be the case that from an evolutionary perspective, ketosis was signalling a lack of calories, and the higher metabolism was pushing us to go find calories? Of course, it has it's uses today in our bubble of excess calories, but part of me really wonders if this is optimal or just a survival mechanism.

    • Stephan C
      Stephan C 11 months ago

      Ketosis is a function of low insulin, not low energy. You can have an excess of calories and still be in ketosis.

  • drewpamon
    drewpamon 3 years ago +93

    We've been living off carbs for so long that we think of the emergency energy source (glucose) is the normal source and the normal sources (fat and protein) are the backups.
    Glucose is a quick and dirty way to supply energy and to store up fat in times that fat and protein are scarce

    • Asar Cadyn
      Asar Cadyn 10 months ago +1

      @Dan lee I think that is not correct. The brain uses loads of ketones when they are available.

    • Asar Cadyn
      Asar Cadyn 10 months ago

      @TheGermTheoryHoaxSlayer Because glucose is important, just not so much of it.

    • Ellenor Bjornsdottir
      Ellenor Bjornsdottir Year ago +1

      @david c a diet of veggies, legumes and grains is nutritionally insufficient. keto is sexy because it shreds fat fast, free of malnutrition.

    • Ellenor Bjornsdottir
      Ellenor Bjornsdottir Year ago +1

      @Dan lee So what are ketones for and why can the brain use them?

    • Ellenor Bjornsdottir
      Ellenor Bjornsdottir Year ago +1

      @TheGermTheoryHoaxSlayer dietary glucose is unimportant. glucose overall is important.

  • Danny Basquez
    Danny Basquez 4 years ago +3

    Very interesting, I would love to see a video of the Q & A portion as well.

  • Rich T.
    Rich T. 2 years ago +6

    good stuff. makes sense. working for me. eat till you are full. low carb. good fat. good, modest protein....easy as pie.

  • Mike Smith
    Mike Smith 7 months ago +3

    As a new type two diabetic, and spending my career in the medical field, I couldn’t figure out why they were not testing insulin level or output. If I’m insulin resistant can you don’t know the insulin output of the pancreas how in the world would giving More insulin solve the problem.

    • JuliaCherrylicious
      JuliaCherrylicious Month ago

      because the old treatment focuses on glucose. It's also not widely known that diabetes type 2 is reversible

  • John Strain
    John Strain 4 years ago +54

    Another brilliant Low Carb Down Under post!

  • adVanture
    adVanture 4 years ago +15

    I would love to see a video where he goes more in depth like he was saying he'd like to

  • Pepe's bodega
    Pepe's bodega 2 years ago

    I'm about 2 weeks into keto diet and I was thinking about the wasting part of the ketone diet as well. Have someone don the math on how many calories one would waste just by pissing and breathing out ketones?

  • Adrian Pollard
    Adrian Pollard 3 years ago +1

    I was wondering if on the flip side of this, can this endocrine theory account for why so many people say they feel cold when their insulin is high as a result of a high sugar diet?

    • Wendy Clare
      Wendy Clare 9 months ago +1

      I am insulin resistant (no meds) and frequently feel icy cold, even my normally warm hands. I hibernate in a blanket if I can. I hoped this meant my ketosis was revving up. Apparently the opposite, my insulin is high, preventing fat burning.

  • Alan Hornkohl
    Alan Hornkohl 3 years ago

    Great explanation!! Very interesting

  • Jose Adrian Burgos Burgos

    Excelente presentación amigo.

  • Brasil66
    Brasil66 4 years ago +3

    brilliant stuff. thanks for posting

  • Blackbird Singing
    Blackbird Singing 3 years ago +4

    I love this mans brain! My favourite fat is scrapped off my fatty roasts!yummy:)Brilliant lecture Proffesor,now go teach our M.Ds some real science( please).

  • Daniel Stapler
    Daniel Stapler 3 years ago

    25:12 I once did some calculations based on the mmols on a ketostix for piddling on and worked out that not many ketones in absolute terms ended up in my urine. Was I wrong? how many Kcals actually end up in your urine? Ok Here are the calculations 3 mmol/L = 17.5mg/dL = 175 mg/L = 1gram per 5.7 litres of Urine. 1 gram Ketones = 9 Kcal I guess, so nearly 6 litres of urine (over 1.5 gals) = 9 Kcal Are these calculations right or wrong?

  • Trejo's World
    Trejo's World Year ago +4

    33:02 “Eat when you’re full.” That’s all I got from this talk and I’m doing it now!

  • Luke Schneider
    Luke Schneider 4 years ago +35

    Great !!! I wish I knew this 10 years ago !!

  • David Wyant
    David Wyant 4 years ago

    Ben , hope you can answer this . Is the effect of insulin and ketones (especially on in vitro stem cells) classified as an epigenetic effect ?

    • Jefferdaughter
      Jefferdaughter 4 years ago +1

      Hey, David. Have you tried contacting Dr. Benjamin Bikman directly? An Internet search will no doubt bring his email address at the university where he works to your fingertips. It is unlikely that he reads the comments posted to the Low Carb Down Under channel on RU-clip.Or, you could ask someone like Dr. Bruce Lipton. The answer depends largely, it seems to me, on how someone is defining 'epigenetic', but my understanding is that epigenetic effects are those which are inherited, or may be passed on to a future generation but are not part of the organism's specific DNA. In that case, the answer might be no, that this effect is purely environmental, maybe. Regardless, it is important that we all remember that 'no gene operates in a vacuum'. (M. Bowling, geneticist) Nearly every trait that we can see or measure in an organism is the result of a complex interplay between the genes and the environment. Where that constitutes simple environmental influence and where that becomes epigenetic may be largely a matter of human perspective and an artificial distinction. It may be similar to the way our classification of the species and distinctions between genera, species and whether or not a natural variation constitutes a separate species is really all about a human construct we impose on the natural world. In broad strokes, the distinction is obvious: a rhinoceros is not related to a daisy. But the distinctions between species and subspecies and hybrids (natural and man-made) of daisy is not quite so clear-cut.It was a pleasure to see an intelligent comment here on RU-clip. Thank you.

    • imchepilo
      imchepilo 4 years ago

      David Wyant do you mean the shift to higher levels of mitochondria and the shift to burn over store? Another factor that is significant is UV light particularly in the 600-700 and 800-900 nm ranges. Also fat cells hoard toxins at different levels and a "toxin loaded" cell will release differently than a higher lipid loaded cell.

  • Loveland Medical Clinic

    great explanation of insulin

  • lindael2
    lindael2 4 years ago +11

    I am going to watch this for the second time. Sent a link to my Dr. Great information.

  • videos
    videos 4 years ago +3

    Been living on 20 carbs a day (at 8pm) for the past 2 years. (And lost 80 pounds). The past week I took 80 grams of carbs 2 times a day. Feeling sick, tired and strange feeling in arms and legs, especialy 1 hour after eating the carbs. Now going back to less carbs, trying 40 grams of carbs a day this week.

    • Deuki Ray
      Deuki Ray 4 years ago

      hi, Are you eating greens, garlic or Apple cider vinegar?

  • L A
    L A 4 years ago +1

    I started doing this diet, I feel hot all the time and my blood sugar has dropped a lot making me hypoglycemic. Is this normal?

  • Chandra Minick
    Chandra Minick Year ago +2

    At the end of this video he talks about a wasting of energy accounting for the removal of some calories from the body inferring that the wasting of energy as well as the ideas of thermodynamics (calories in and calories out) and the endocrine system (hormonal regulation of what calories get burned) are three mechanisms that determine weight loss or gain.
    So basically this could explain because of the wasting of energy why calorie counting does not work for weight loss in the long run, and why eating an excess of fat calories on a ketogenic diet with intermittent fasting could cause weight loss even though the calories are higher than what we need for our daily or weekly maintenance calories. Rather than naming the video "The Fght for Brown Fat" it should have been named "Where is Your Calorie Counting God Now?"

  • Snit 77
    Snit 77 4 years ago +6

    thx, keep those videos coming

  • Robert Laslo
    Robert Laslo 2 years ago +5

    Ketogenic wasting probably includes perspiration as well as the other two means because my body odor changes during ketosis indicating that sweat may be another way to waste.

    • ubuu7
      ubuu7 7 months ago

      Do you smell worse on keto sweat?

  • Bernardo Rojas
    Bernardo Rojas 2 months ago

    Has anyone else heard👂 that sea kelp consumption help with the conversion of WAT tissue to BAT for body absorption through the blood and out through the lungs as CO2. Fat turns to CO2 then as opposed to getting sweated out ?

  • Gus Kale
    Gus Kale 2 years ago +4

    Gotta love science.

  • Ms. Crystal
    Ms. Crystal 2 years ago +5

    But how do levels of ketones affect the liver?

    • Chappy P
      Chappy P Year ago

      Liver creates the ketone level. It converts fat acids to ketones and puts them in the bloodstream for energy.

  • Benyamin Mentchale
    Benyamin Mentchale 8 months ago


    I have a question regarding Keaton.

    Are Ketons used, as an input, to create energy, in the cell?
    Are Ketons, the output, of the energy creating process, in the cell?

  • Vaughn Malecki
    Vaughn Malecki 3 years ago +2

    Perhaps my access body fat I'm still hanging on to isn't as unhealthy as I thought. Maybe my body doesn't want to "waste energy" so it hangs onto it and stores it quite easily. 🤔

    It kinda makes sense now why people say "just stick with it" and six months later they suddenly begin to see results of more muscle tone happening.

  • Risingnshouting
    Risingnshouting 4 years ago

    Great presentation! I'm just up the road in SLC. Check my user name for Y fan credentials :-). Willing to be a human test for your studies. Been on a keto diet for about 6 weeks and doing relatively well. Cheers

  • puremaze
    puremaze 4 years ago +7

    I have 3 important questions:
    (1) will the body enter ketosis when food intake has less than 20g carbs and moderate protein more easily if there is an important fat intake, or will the body need to be kickstarted with important amounts of fat?
    (2) If the body enters ketosis just as easily without fat intake, can the body and the brain in particular use those ketones for fuel without that fat intake or does it need to be trained with actual fat consumption?
    (3) Are ketones produced out of own body fat excreted through urine more easily than ketones produced through fat intake?

    My thinking is that since people who are fasting for more than a few days have good mental clarity and energy, high fat intake is not necessary to a ketogenic diet - as long as own fat reserves are sufficient and the typical fat transported vitamins are not lacking. Is this assumption correct?

    • Victor Ibiyemi
      Victor Ibiyemi 4 years ago +4

      Fat does produce an insulin response when ingested, any food does , however the insulin response from fat is not of the same magnitude of that from carbs and from some extent protein

    • michael Cariello
      michael Cariello 4 years ago +3

      Laurent Grimal here is my thinking on your question. Fasting long enough will bring on ketosis. However, at some point we will have to eat. To stay in ketosis and take in nutrition on an everyday basis it must be a higher fat diet. Fat is the only macronutrient when ingested does not provoke an insulin response. So eating a high fat diet allows you to eat everyday without the body ever coming out of ketosis. So if you plan on eating everyday and want to remain in ketosis a majority of your calories must come from fat.

    • Carroll Hoagland
      Carroll Hoagland 4 years ago +2

      Laurent, good analysis. The trigger is in the liver when it senses "Low Glucose" or glycogon stores in the liver - it either uses available carbs to make glucose or stores it as fat. If the carbs are not present, it then signals adipose tissue to release fats. Dr. Bikman and Mike from High Intensity Health have a "New" discussion on Hormones and metabolic feed back systems. He goes more into science in this discussion ...
      LOL www.70GoingOn100.com the Centenarian Diet, or maybe 128, the Hayflick limit, or if a Ray Kurzweil fan then this is a Moot Point …

  • Rockford Wellington, III

    Great video!!!

  • Bao Vuong
    Bao Vuong 2 years ago

    Great videos!

  • spaniol1997
    spaniol1997 Year ago

    So if you take an exogenous ketone supplement, while still taking in carbs that elevate insulin, do they cancel each other out or does one trump the other?

  • Jennifer Lewis
    Jennifer Lewis 10 months ago +1

    Wow! Who'd have thought the fact babies and toddlers are pot-bellied may be a key factor in the survival of the human race... Mind: Blown.

  • David Pannell
    David Pannell Year ago

    Also I'm curious if there is a ceiling to this behavioral transfer between WAT & BAT and would the ceiling even be a substantial difference in a BMR bump?

  • inoebene
    inoebene 3 years ago

    The Insulin Master.. 🙏

  • Amy Wilde
    Amy Wilde 3 years ago +1

    DR. Bickman mentions pairing up with a bariatric clinic to test the patients - has that testing/study/ findings been published yet?